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Protecting Against Polio

The First Oral Live-Attenuated Poliomyelitis Vaccine in Dragee Candy in China

In newly founded China, in order to guarantee that the children from remote areas can immunize with poliomyelitis vaccines, scientists in IMBCAMS developed a unique dosage form of OPV, the dragee candy with improved thermostability.

With continuous efforts, an independently established human diploid cell line, KMB17, replaced the initially used monkey kidney cells as cell substrates, which improves the quality of our products.

With continuous efforts, an independently established human diploid cell line, KMB17, replaced the initially used monkey kidney cells as cell substrates, which improves the quality of our products.

The First Inactivated Poliomyelitis Vaccine Made from Sabin Strains (Sabin IPV) All Over the World

30 years tackling and the joint efforts from three-generation researchers fruited the first IPV made from Sabin strains.

Both the Sabin strain viruses and Vero cell substrates used in manufacturing are provided by WHO.

Utilizing the technology of scaled-up culture in bioreactors with microcarriers during production.

Down-stream processing purification technology guarantees the high purity of Sabing IPV.

The Best Weapon for Human to Eradicate Poliomyelitis

Sabin IPV is developed from attenuated Sabin strains polioviruses that are provided by WHO, which avoids potential biosafety risks by the use of wild type strains and could be manufactured under level 2 biosafety circumstance.

The use of inactivated vaccine absolutely eliminates the incidence of vaccine-associated paralytic poliomyelitis (VAPP) and vaccine-derived poliovirus (VDPV). It makes the Sabin IPV has the characteristics of attenuation and inactivation, which is called double lock.

Sabin IPV can induce protective antibodies against all epidemic wild polio virus strains and most VDPV strains. The GMT are all significantly higher than protective level (GMT>8).

Eradicating Polio, We Have Been Working Hard

Polio is a disease that falls into the most challenging goal-eradication. There is no cure for Polio, but safe and effective vaccines can prevent it.“The partners of the Global Polio Eradication Initiative are cheering IMBCAMS on. In addition to the World Health Organization, which has been engaged closely with IMBCAMS, the Bill and Melinda Gates Foundation has also been working closely with IMBCAMS to encourage prequalification of Sabin IPV for use globally through UNICEF’s and Gavi’s global procurement to help children in countries that do not make vaccine. The world is a safer place because of IMBCAMS’s scientists, engineers, management, and leadership.”

——Lance E Rodewald

WHO China Country Office, at foundation stone laying ceremony of phase II production base"

The construction of Phase II production base of Sabin IPV is accordance with the requirements of WHO PQ certification

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